Syndromic Approach to Parkinson's Disease: Role of Functional Imaging
Identifieur interne : 002709 ( Main/Exploration ); précédent : 002708; suivant : 002710Syndromic Approach to Parkinson's Disease: Role of Functional Imaging
Auteurs : Chong Sik Lee [Canada] ; Sun Ju Chung [Corée du Sud] ; Jae Seung Kim [Corée du Sud]Source :
- Journal of Clinical Neurology (Seoul, Korea) [ 1738-6586 ] ; 2006.
Abstract
Current evidence from monogenic Parkinson's disease (PD) supports the view that PD is a clinical syndrome, rather than a single disease entity, and that the heterogeneity of PD indeed reflects different pathogenesis. Recent developments in functional imaging have enabled the in vivo assessment of cellular and molecular pathology of PD with respect to temporal and topographical patterns. We propose that this new technology will be useful for linking monogenic and sporadic PD, and thus, for classifying PD based on the pathogenesis. It will be also useful in clinico-genetic studies exploring susceptibility factors and at-risk groups, which are important for neuroprotective treatment when it becomes available.
Url:
DOI: 10.3988/jcn.2006.2.2.83
PubMed: 20396491
PubMed Central: 2854957
Affiliations:
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wicri:curation="lc">Canada</country><wicri:regionArea>Department of Medicine/Neurology, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Neurology, College of Medicine, University of Ulsan, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Neurology, College of Medicine, University of Ulsan, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jae Seung" sort="Kim, Jae Seung" uniqKey="Kim J" first="Jae Seung" last="Kim">Jae Seung Kim</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Nuclear Medicine, College of Medicine, University of Ulsan, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Nuclear Medicine, College of Medicine, University of Ulsan, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of Clinical Neurology (Seoul, Korea)</title><idno type="ISSN">1738-6586</idno><idno type="eISSN">2005-5013</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Current evidence from monogenic Parkinson's disease (PD) supports the view that PD is a clinical syndrome, rather than a single disease entity, and that the heterogeneity of PD indeed reflects different pathogenesis. Recent developments in functional imaging have enabled the in vivo assessment of cellular and molecular pathology of PD with respect to temporal and topographical patterns. We propose that this new technology will be useful for linking monogenic and sporadic PD, and thus, for classifying PD based on the pathogenesis. 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uniqKey="Mcgeer E">EG McGeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerhard, A" uniqKey="Gerhard A">A Gerhard</name></author><author><name sortKey="Pavese, N" uniqKey="Pavese N">N Pavese</name></author><author><name sortKey="Hotton, G" uniqKey="Hotton G">G Hotton</name></author><author><name sortKey="Turkheimer, F" uniqKey="Turkheimer F">F Turkheimer</name></author><author><name sortKey="Es, M" uniqKey="Es M">M Es</name></author><author><name sortKey="Hammers, A" uniqKey="Hammers A">A Hammers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonifati, V" uniqKey="Bonifati V">V Bonifati</name></author><author><name sortKey="Rizzu, P" uniqKey="Rizzu P">P Rizzu</name></author><author><name sortKey="Van Baren, Mj" uniqKey="Van Baren M">MJ van Baren</name></author><author><name sortKey="Schaap, O" uniqKey="Schaap O">O Schaap</name></author><author><name sortKey="Breedveld, Gj" uniqKey="Breedveld G">GJ Breedveld</name></author><author><name sortKey="Krieger, E" uniqKey="Krieger E">E Krieger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canet Aviles, Rm" uniqKey="Canet Aviles R">RM Canet-Aviles</name></author><author><name sortKey="Wilson, Ma" uniqKey="Wilson M">MA Wilson</name></author><author><name sortKey="Miller, Dw" uniqKey="Miller D">DW Miller</name></author><author><name sortKey="Ahmad, R" uniqKey="Ahmad R">R Ahmad</name></author><author><name sortKey="Mclendon, C" uniqKey="Mclendon C">C McLendon</name></author><author><name sortKey="Bandyopadhyay, S" uniqKey="Bandyopadhyay S">S Bandyopadhyay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author><author><name sortKey="Goedert, M" uniqKey="Goedert M">M Goedert</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Lee, Chong Sik" sort="Lee, Chong Sik" uniqKey="Lee C" first="Chong Sik" last="Lee">Chong Sik Lee</name></noRegion></country><country name="Corée du Sud"><noRegion><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name></noRegion><name sortKey="Kim, Jae Seung" sort="Kim, Jae Seung" uniqKey="Kim J" first="Jae Seung" last="Kim">Jae Seung Kim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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